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Hi Howard and welcome. Yes Sir, this ammunition is compatible with the Ruger LCR 22Mag Revolver. Cheers and stay safe!

Howard, yes sir as long as you have the 22 mag/wmr version and not the 22lr version. If you have the 22mag version then yes this will fit and function just fine. Hope this helps.

Howard, it is if you mean the LCRx chambered for .22wmr (22mag). Otherwise, the LCR 22 is chambered for .22lr, which is a different caliber than .22mag. You want .22lr ammo, such as this - budsgunshop.com/product_info.php/products_id/130684/federal+premium+personal+defense+.22+lr+29gr+punch+flat+nose+50rd+box , Stay safe & have a great day!