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No, there are no factory Glock models with a thumb safety. Safety mechanisms for all Glock pistols consist of their trigger safety and internal firing pin and drop safeties.

Even though the Glock does not have an external manual safety, it incorporates three internal safeties intended to prevent the gun from discharging if dropped or jostled. A unique feature of the Glock is that a shooter disengages all three safeties at once by pulling the trigger.