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George, yes sir, this will work in your M&P Sport II. Stay safe & have a great day!

These Will fire through your M&P with no issues. Load'em up and Send'em!!

Hi George and welcome. Yes, the Smith and Wesson M & P 15 sport 2 AR 15 rifle is barrel stamped 5.56NATO and will fire both 5.56 and .223 ammunition no issue. Cheers and stay safe!