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all of the above can and will be a good home defense option I would recommend the .38 special/.357 and the 20 ga over the .41 mag (unless you are a reloader) due to the wider selection of loads available in them
38 special gets my vote. Remember you can shoot both 38 and 357.
Do you want to kill someone or just hurt them?
you can shoot .357 and 38 special ONLY if it is a .357 chambered gun
The 30 Special would be sufficient (I would get the .357 version) and load with 38special. The 41 Magnum is definitely a bit much in recoil and muzzle blast (I.E. ringing ears if inside). The 20ga is great for home defense with #4 Buck Shot load. The business end will be further from your ears and will possible end a threat with just one shot. 38/357 and 20ga are just about a tie but I would give the nod to the 20ga.