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Yes it will, I carry this exact setup!

the holosun 507k x2 fits the same mounting plate as the Romeo Zero. so it will fit the plate on the sig just fine

Hi John, yes, the HS507K X2 is an open reflex optical sight designed for subcompact pistol applications. The Holosun 507K will mount directly to any slide designed for the Shield RMSc, which is the footprint on this Sig P365. Stay safe & have a great day!

Hi John and welcome. Yes Sir, the Holosun 507K x2 will be a direct slide mount on the Sig Sauer P365 9mm Optic Ready Semi Auto Pistol. Cheers and happy holidays to you and yours!