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Hi Steven and welcome. No Sir. 22lr only. Cheers!

Hi Steven, no sir, this gun will fire .22lr, .22 shorts, or 22 long.......22 magnum is an entirely different round. The 22 magnum version is here https://www.budsgunshop.com/product_info.php/products_id/36683/henry+golden+boy+.22+mag , Stay safe & have a great day!