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Hi Gary and welcome. The SP101 (Have not heard of a GP101) (mislabeled maybe?) has a smaller, lighter frame than the GP100. Full details of the differences here - https://www.targetbarn.com/broad-side/ruger-sp101-vs-gp100/

the GP100 will be closer to your security six the Gp100 is a little larger and much stronger action it replaced the security six The SP101 is a small compact revolver made for carry there is no GP101 https://ruger.com/products/sp101/overview.html and https://ruger.com/products/gp100/overview.html

Hi Gary, did you mean SP101? The SP101 is a smaller, more compact revolver with a shorter barrel. The GP100 would be closest to the Security Six. Stay safe & have a great day!