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Hi Don, no sir. .22 shorts will not cycle or feed properly. Stay safe & have a great day!

That's probably not a good idea as the shorties won't cycle properly if at all.

Hi Don and welcome. No reliably as the slide weight and recoil spring are tuned for standard 22LR ammunition. Cheers, stay safe and enjoy!

sorry the shorts just dont have enough recoil for them to operate the slide