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Absolutely!!! As with any defensive round, you want to fire maybe 50+ Rounds to make sure there are no cycling issues. After all, your life may depend on them!

Hi Cody and welcome. It will work but there are substantially better performing rounds for self defense : https://www.budsgunshop.com/product_info.php/products_id/92648/sig+sauer+elite+performance+9mm+jhp+124+gr+20rd+box -- Cheers, stay safe and enjoy!