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Hi Linda, these (full metal jacket) are best suited for range use. For defense you want hollow points. budsgunshop.com/product_info.php/products_id/98607/nosler+51279+match+grade+40+s%26w+180+gr+jhp+20+bx+20+cs , Stay safe & have a great day!

Hi Linda and welcome. Yes but, they won't have the same stopping power as a good hollow point round such as : budsgunshop.com/product_info.php/products_id/74197/pmc+40+smith+%26+wesson+165+grain+jacketed+hollow+point+50rd+box ---------- Cheers, stay safe and enjoy!