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Yes, and so will .38 special. Any revolver, or in this case a Derringer, chambered in .357 mag can also shoot .38 sp.

Hi Justin and welcome. If your derringer is chambered in .357 Magnum then you are good to go. Since .357 Magnum is a handful in a derringer, you could also shoot .38 Special --- https://www.budsgunshop.com/product_info.php/products_id/55986/fiocchi+.38+spc+125+grain+semi+jacketed+hollow+point ---- Cheers, stay safe and enjoy!

Hi Justin, yes sir, as long as your derringer is chambered for .357 Stay safe & have a great day