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The MKIV 22/45 Tactical has a Barrel is threaded 1/2"-28 for accessories -This is designed for the MKIV 22/45 - https://www.tandemkross.com/22-Muzzle-Brake-22-45-Compensator

http://www.maddmacsprecisiontactical.com/ruger-2245-lite-compensators.html

here is the best on the market https://www.tandemkross.com/22-Muzzle-Brake-22-45-Compensator