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Hi Patricia, yes these will work in the KelTec P17 22lt. Per the owners manual - "The P17 pistol has been designed and chambered to operate with standard .22 LR cartridges that are HIGH VELOCITY AMMUNITION ONLY. Use only brass-cased ammunition." Stay safe & have a great day!

Hi Patricia and welcome. It should work. I recommend buying a small lot of different types of ammo, testing to see which perform reliably in your firearm, then stocking up since the tolerances can be different in the same firearm model. This is recommended since ammo cannot be returned. Cheers stay safe and enjoy!