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Hi James and welcome. No. Straight from Rossi's owner's manual - There are only four calibers that can carry a ''+P'' rating from SAAMI. They are 38 Special +P, 9mm Luger +P, 38 Super Automatic and 45 Automatic +P. There are no other SAAMI approved ''+P'' loads. Any ammunition in any other caliber marked ''+P'' is not SAAMI compliant, may be dangerous and should not be used. https://rossiusa.com/images/manuals/Rossi%20USA_Polymer%20Pistol%20Manual.pdf

Hi James, no sir, 45LC +P ammo is not SAAMI rated and should not be used. Stay safe & have a great day!