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Hi Phil and welcome. The 45LC is ok for deer hunting but not much past 150 yards. Ammunition selection will be the deciding factor. Some recommendations here: https://www.budsgunshop.com/product_info.php/products_id/157096/winchester+big+bore+45+colt ---------------------------------------- https://www.budsgunshop.com/product_info.php/products_id/713098733/underwood+.45+lc+255gr

For sure you can take down deer at ranges up to 150 yards but ammo will be a big factor.