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Hi Keat, no, from the owners manual - "Beretta specifically disclaims responsibility for any damage or injury occurring with, or as the result of, the use of faulty, non-standard, "remanufactured," hand-loaded or reloaded ammunition. Use only high-quality, commercially-manufactured ammunition made in accordance with CIP (Europe and elsewhere) or SAAMI® (USA) standards." There is no SAAMI standard for .380 +P ammo. Stay safe & have a great day!

Hi Keat and welcome. For safety and warranty reasons, no Sir according to Beretta. Standard SAAMI pressure .380ACP ammunition only. Cheers. stay safe and enjoy!