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Hi Ebiye and welcome. No Sir. Only 22LR ammunition should be used. The difference in size is here: https://www.ammoman.com/blog/testing-380-vs-22/

Hi Ebiye, you cannot use .380 in this gun. You can only use .22lr ammunition. https://www.budsgunshop.com/search.php/type/ammo/caliber/10000844-22+long+rifle , For varmints or defensive purposes use hollow points https://www.budsgunshop.com/product_info.php/products_id/62144/cci+small+game+subsonic+.22+lr+40gr+lead+hollow+point+100ct+box , Stay safe & have a great day!