Yes it is removable from the PK380 owners manual Page 27 "Walther Arms laser
The laser was developed especially for the PK380 and is designed to be a perfect fit. The quick-release catch allows
the laser to be mounted or removed instantly without the need for additional tools. LEDs on either side of the laser,
illuminate indicating that the laser is on. Standard equipment incl. batteries and adjustment wrench." link waltherarms.com/wp-content/uploads/Instruction-Manual-for-PK380.pdf

Why do you want to remove it? There are holsters made to fit both the gun and the laser, if that's your issue with it.

Hi Thomas, Yes it is removable with just a couple small screws.

Yes, it's easily removable as it is attached via the bottom rail on the pistol. Takes only a few seconds - Image removed here : raven1tactical.com/1452-thickbox_default/walther-arms-pk380-laser-sight-.jpg