Hi Wayne, the 455 Varmint will have better accuracy all day long. Expect about a quarter inch better accuracy if the shooter is up to the task.

I have both the American and a Varmint while the Accuracy (in theory) may be slightly better with the Varmint in the real world you could get a American that is more accurate due to good luck (just a tight gun) . in real world accuracy for me the guns are even

Wayne, the 455 Varmint will have better accuracy all day long. Expect about a quarter inch better accuracy if the shooter is up to the task.