Gilbert, No the P365 will not shoot itself. The trigger must be pulled with a round in the chamber and firearm in battery. A quality holster that covers the trigger is a must. The P365 will only discharge if the trigger is pulled. It does not shoot itself.

not unless something or someone pulls the trigger as said use a good quality holster that cover the trigger and you will be fine

Gilbert, no Sir. As long as you use a quality holster that properly covers the trigger. There is also a "Manual Safety" version of this pistol here : budsgunshop.com/catalog/product_info.php/products_id/108733/sig+sauer+3659bxr3ms+p365+micro-compact+9mm+luger+double+31+10%2b1+ms+black+po