Jason, This firearm has a transfer bar firing pin safety. So you can load all cylinders. Transfer bar will not allow hammer/ firing pin to strike primer without the trigger being pulled to the first stage. Drop safe.

Jason, this is the 3-Click Transfer Bar (safe for loading all six rounds) version and not the earlier 4 - Click with no transfer bar safety that you needed to only load 5 rounds to safely carry.

The firing pin is mounted to the hammer which has a lightly checked spur for improved cocking. As a single-action revolver, the hammer must be fully cocked for each shot fired. It should be noted here that the hammer has three positions, each of which is accompanied by a distinctive “click” as the hammer moves through its arch of travel. The first click is the safe position.*** Thanks to a modern hammer safety, not found on the original 1873 model, the Cattleman revolvers can be carried with all six chambers loaded when the hammer is in this first position. The second click frees the cylinder to rotate clockwise for loading. The third click is fully cocked. With the hammer in this position the revolver is ready to fire.