Yes, CCI is one of the more reliable rounds of ammo for the M&P 15-22. I've had no issues using it in mine.

yes it will CCI mini mags are my go to 22lr ammo if a gun will not work with them the gun needs repair

John, Yes that round is one of the most consistent dependable rounds you can use in any 22 lr semi-auto firearm. The CCI Mini Mag 36 gr CPHP will function great in your S&W M&P15 22 Sport.

John, yes Sir. It will fir without issue. CCI is very consistent rim-fire ammunition and functions well. Cheers!