I would look at TNW : tnwfirearms.com/product-p/asrx-cplt-9445-xxxx-xxxx.htm
Or
These guns use an adapter/chamber sleeve to be able to fire multiple calibers. There are break open single shot shotgun out there that does this. Check out X-Caliber X-treme and Chiappa X-Caliber
Also Great article on modern survival website here https://modernsurvivalonline.com/top-multi-caliber-guns/

Tyler, the 22-250 to 22LR Adapter used to be common but are hard to find now. There were other calibers such as .223 to 22LR adapters as well. Example : https://collectibleammunition.com/product/22lr-to-22-250-chamber-adapter/