Even though .22LR and .22WMR are both rimfire cartridges, they are not compatible with each other. With a few exceptions, guns that are chambered in .22LR will not shoot .22WMR, and vice versa.
22LR and .22WMR ammunition are both rimfire cartridges that shoot bullets that weigh around 40 grains. That’s where the similarities end. As was said before, most guns chambered in one caliber will not work in the other. However, Ruger makes a single-action rimfire revolver, the Convertible Single Six, that has interchangeable cylinders, one in .22LR and the other in .22WMR.
You might be tempted to shoot .22LR in a gun that’s chambered in .22WMR. After all, the shorter length and lighter power of .22LR vs .22WMR means that, technically, it will fit into a .22WMR gun. Resist that temptation. It’s true that a round of .22LR will fit inside the chamber of a gun that shoots .22WMR. However, the .22LR fits loosely in the chamber. The .22LR cartridge case is narrower than that of .22WMR. This means it will fit in the chamber, but if you try to fire a .22LR round out of a gun that uses .22WMR, the case will expand inside the chamber when fired, to the point where it may become dangerous.

Only 22 WMR. 22 WMR was designed to fully enclose the bullet while 22LR grips the heel of the bullet. A 22LR wouldn't fit properly and most likely damage the gun if tried.

Daryl, only 22wmr. You would need a 22lr specific cylinder to fire 22lr. Cheers and stay safe!