My wife uses a Walther p22 and the two I choose for her pistol is cci stingers there 32gr and 1640fps one of the fastest 22lrs you'll find. Another great one is cci velocitors I like the heavier grain of 40gr and 1435fps. There two I can consistently rely on and the tx22 isn't as picky as a Walther p22 so shouldn't have any reliability issues.

Steven, some of the best defense 22lr are : shtftactical.com/products/ammo-cci-962me-604544663662-913 -------------- https://ammo-shop-com.3dcartstores.com/-IN-STOCK-NOW-CCI-Mini-Mag-22LR-32-Grain-STINGER-Copper-Plated-Hollow-Point--1640FPS--50-Round-Packs-IN-STOCK-NOW-_p_29.html