Its not offered by Ruger if you want 22 Mag go with the single six combo or the Heritage Rough rider combo

No wrangler but the Single 9 is available in 22wmr
budsgunshop.com/product_info.php/products_id/83632/ruger+8150+single-nine+9rd+22+mag++65

Joseph, some owners have said the Single Six 22 Mag Cylinder works and a few said no. I would read here and contact Ruger for advice : rugerforum.com/phpBB3/viewtopic.php?t=293235

No, the Wranglers only in 22lr. If you want a good but inexpensive 22lr and mag revolver I own the heritage rough rider and for being a cheaper pistol it's actually great and very accurate. Hope this helps.