Hi John and welcome. Mostly any full-sized handgun will work no issue. Even mid-sized and compact models have extended magazines available with extensions to give a full-sized grip in a more concealable package. Just pick the manufacturer model, caliber you want and then get the right magazine option if compact or just get a full-sized handgun off the rip. Options are virtually limitless. Cheers, stay safe and enjoy!

Depending on what you want to use it for I'd say go full size walther pdp or some say glock have a larger grip I have large hands as well and can comfortably grip both