Hi Thomas and welcome. Yes and no issues.
Byrna Technologies Less-Lethal 12 Gauge Kinetic Round Specifications and Features:
Item Number: SS61301
12 Gauge Kinetic Round with Clamshell Sabot Jacket
Length: 2-1/2"
Velocity: 312 fps
Muzzle Energy: 14.75 ft/lbs
Effective Range: 5'-100'
Fin-Tailed Technology for Enhanced Accuracy
No Gunpowder, Uses a Shotgun Primer for the Propellent
16x Quieter Than a Standard Shotgun Round
Almost No Perceived Recoil
Box of 10 Less Lethal Kinetic Rounds
Note:
Designed for Use in All 12-gauge Shotguns with a Cylinder or Improved Cylinder Bore
Tested Extensively with Remington 870, Mossberg 590, and Kel-Tec KSG
Will NOT Cycle Semi-Automatic Shotguns, But Can be Fired and Cycled Manually
NEVER Mix Less-Lethal and Lethal Ammunition in the Same Magazine
Cheers, stay safe and enjoy!

yes they will work just fine however they will not cycle semi autos

Hi Thomas, this can be used in shotguns with 2.75" or 3" chamber. The 12 gauge rounds work with standard cylinder bore and improved choke shotguns only.
The 12 gauge rounds were designed to work in a pump action or single shot shotgun and will not cycle a semi automatic shotgun as they do not contain gunpowder. They can be manually cycled and fired through most semi auto shotguns.
Stay safe & have a great day!