No, a Savage 10/110 Axis II Short Action 10-round magazine will not work with the .22-250 Remington cartridge, as the Axis II is a long action rifle and .22-250 is a short action cartridge.
Here's why:
Action Length:
The Savage Axis II is a long action rifle, meaning it's designed for longer cartridges.
.22-250 Cartridge:
The .22-250 Remington is a short action cartridge, meaning it's designed for use in rifles with a shorter action.
Magazine Compatibility:
Because the Axis II is a long action rifle, it uses magazines designed for long action cartridges, not short action cartridges like the .22-250.
Savage Axis II and .22-250:
The Savage Axis II is not chambered in .22-250, and therefore, it is not designed to use .22-250 cartridges or magazines

Hi John and welcome. No Sir, this is for .308, .243 and 6.5 Creedmoor. Cheers and stay safe! You would need this magazine: https://mdttac.com/us/22-250-mdt-metal-aics-magazine-10-rnd