Mike, The pistol grip feels very natural and comfortable in the hand and while it is thick, it does not have palm swells and should fit just about everyone’s hands nicely. The shape and location of the pistol grip does align the trigger finger nicely with the trigger as well which helps promote a good trigger squeeze. Both the buttstock and then pistol grip are shaped to allow firing the rifle either right or left handed as there is not a left handed bolt version available. With the "Thumb Cutout" on the left side it will be slightly less ergonomic for left hand shooters since it automatically positions the thumb alignment for comfort.

Mike, It will shoot great for a left hander. If you go to the video on model 11686 the 308 MVP LR model they have a left hander shooting it. It will feel just fine.