Joshua, The Ruger Mark IV Target does not have a threaded barrel for a suppressor to be mounted to. The Target Exclusive model does. See following:--------budsgunshop.com/product_info.php/products_id/104639/ruger+mark+iv+target+%2aexclusive%2a+single+22+lr+

If the model is threaded yes you can. Some companys make internal barrel/suppressor barrels. Price will depend on company, brand, installation, amongst other stuff.

Joshua, yes, the Threaded Models do Sir. The Threaded Barrel Ruger Mark IV Target models feature a 1/2"-28 thread pattern for popular muzzle accessories. budsgunshop.com/product_info.php/products_id/100057/ruger+40126+mark+iv+target++22+lr+55+10%2b1+syn ------------------------ budsgunshop.com/product_info.php/products_id/3062/ruger+silent-sr+22lr%2f22wmr%2f17hmr+suppressor

This about integral suppressors: http://srtarms.com/22-pistols/
It was my pleasure to somewhat assist you.

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