Yes it will cycle, ball ammo will have almost no expansion though, expansion is what's going to help slow the bullet down in soft targets, while increasing surface area, which is what helps prevent over penetration and causes maximum damage to your attackers.
Here is a list of in stock 45acp Defensive ammo, including JHP, and Francine ammo ( it won't let me link to the filtered list, at the top select ammo type "defensive" to narrow your search)
ammobuy.com/ammo/45-acp-auto
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Half way down the page is speer gold dot, and federal HST which are 2 of the best defensive ammo you can get in many calibers (including 45acp)

Caleb, It would work but not be optimal due to and potential pass through/over penetration liability. Cheers and stay safe!