No, it will not work due to the sizing difference of the Barrel nut between an AR-15 & AR-10.

Hi David and welcome. No Sir due to Barrel Nut diameter differences. This one will work (just change the (6) in the link to a c). --- (6)dnnsports.com/ar-308-handguard-modular-15in-tacfire.html -------------- Cheers, stay safe and enjoy!

sorry the AR 15 handguards will not fit on a AR10

Hi David, no sir, because of the barrel nut size difference between the AR-10 and AR-15, the handguards and rail systems are not interchangeable.
Here is one that will work >>> opticsplanet.com/presma-ar-10-lr-308-super-light-m-lok-series-free-float-handguards-w-partial-top.html?_iv_parent-gun-make=dpms&_iv_parent-gun-model=dpms-lr-308,dpms-ar-10,ar-10&_iv_code=2HC-HZ-FF13LP-M38MP-L15
Stay safe & have a great day!